Lexapro (Escitalopram oxalate) is the most important drug that is prescribed to treat depression. It works by increasing the amount of serotonin (a natural chemical in your body) which improves mood and other related symptoms of depression. As Lexapro is an SSRI medication, it may increase the risk of bleeding when taken with aspirin, NSAIDs such as ibuprofen (Advil), and other anticoagulants.